Tel: 58 563 4769, E-mail: vaclav.bazgier@upol.cz, Room: 3.009 orcid

Research interests

  • In-silico drug design (molecular docking, chemoinformatics)

Education

  • 2011 – VŠB – Technical University of Ostrava
  • 2014 – University of Ostrava
  • 2018 – Palacký University Olomouc

Employment

  • 2007 – 2009 – Department of Biochemistry, Faculty of Science, Palacký University Olomouc
  • 2009 – 2011 – Department of Immunology, Faculty of Medicine and Dentistry, Palacký University Olomouc
  • 2011 – 2013 – Department of Botany, Faculty of Science, Palacký University Olomouc
  • 2012 – now – Laboratory of Growth Regulators, Palacký University Olomouc
  • 2013 – 2020 – Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc
  • 2020 – now – Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc

Publication

2021

  1. Diachkov MV, Ferrer K, Oklešťková J, Rarová L, Bazgier V, Kvasnica M: Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain. Int. J. Mol. Sci., 22(1), 155, 2021. (DOI)
  2. Kiss MA, Peřina M, Bazgier V, May NV, Baji Á, Jorda R, Frank É: Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer. J. Steroid Biochem. Mol. Biol. , 211, 105904, 2021. (DOI)
  3. Sehnal D, Bittrich S, Deshpande M, Svobodová R, Berka K, Bazgier V, Velankar S, Burley SK, Koča J, Rose AS: Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic Acids Res., 49(W1), W431-W437, 2021. (DOI)
  4. Špičáková A, Kraus P, Gucký T, Kryštof V, Strnad M, Bazgier V, Otyepka M, Kubíčková V, Poruba M, Rácová Z, Zapletalová I, Anzenbacher P: in vitro and in silico Studies of Interaction of Synthetic 2,6,9-Trisubstituted Purine Kinase Inhibitors BPA-302, BP-21 and BP-117 With Liver Drug-Metabolizing Cytochromes P450. Physiol. Res., 69(4), S627-S636, 2021. (DOI)

2020

  1. Šlachtová V, Šebela M, Torfs E, oorts L, Cappoen D, Berka K, Bazgier V, Brulíková L: Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1. Eur. J. Med. Chem., 185, 111812, 2020. (DOI)

2019

  1. Jorda R, Řezníčková E, Kiełczewska U, Maj J, Morzycki J, Siergiejczyk L, Bazgier V, Berka K, Rárová L, Wojtkielewicz A: Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines. Eur. J. Med. Chem., 179, 483-492, 2019. (DOI)
  2. Juračka J, Šrejber M, Melíková M, Bazgier V, Berka K: MolMeDB: Molecules on Membranes Database. Database, 2019, baz078, 2019. (DOI)
  3. Špičáková A, Bazgier V, Skálová L, Otyepka M, Anzenbacher P: Beta-caryophyllene oxide and trans-nerolidol affect enzyme activity of CYP3A4-in vitro and in silico studies. Physiol. Res., 68, S51-S58, 2019. (DOI)

2018

  1. Gucký T, Řezníčková E, Muchová RT, Jorda R, Klejová Z, Malíková V, Berka K, Bazgier V, Ajani H, Lepšík M, Divoký V, Kryštof V: Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl-N6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 mutations. J. Med. Chem., 61(9), 3855–3869, 2018. (DOI)
  2. Pravda L, Sehnal D, Toušek D, Navrátilová V, Bazgier V, Berka K, Svobodová Vařeková R, Koča J, Otyepka M: MOLEonline: a web-based tool for analyzing channels, tunnels and pores (2018 update). Nucleic Acids Res, 46(W1), W368–W373, 2018. (DOI)
  3. Šrejber M, Navrátilová V, Paloncýová M, Bazgier V, Berka K, Anzenbacher P, Otyepka M: Membrane-attached mammalian cytochromes P450: An overview of the membrane’s effects on structure, drug binding, and interactions with redox partners. J Inorg Biochem, 183, 117-136, 2018. (DOI)

2017

  1. Carazo Fernández A, Hyrsova L, Dušek J, Chodounská H, Horvátová A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudová E, Pávek P: Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol. Lett., 265, 86–96, 2017. (DOI)
  2. Huličiak M, Bazgier V, Berka K, Kubala M: RH421 binds into the ATP-binding site on the Na+/K+-ATPase. Biochim. Biophys. Acta, Biomembranes, 1859(10), 2113–2122, 2017. (DOI)
  3. Kořínková P, Bazgier V, Oklešťková J, Rárová L, Strnad M, Kvasnica M: Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study. Steroids, 127, 46-55, 2017. (DOI)

2016

  1. Baltus CB, Jorda R, Marot C, Berka K, Bazgier V, Kryštof V, Prié G, Viaud-Massuard M: Synthesis, Biological Evaluation and Molecular Modeling of a Novel Series of 7-Azaindole Based Tri-Heterocyclic Compounds as Potent CDK2/Cyclin E Inhibitors. Eur. J. Med. Chem., 108(27), 701–719, 2016. (DOI)
  2. Bazgier V, Berka K, Otyepka M, Banáš P: Exponential repulsion improves structural predictability of molecular docking. J. Comput. Chem., 37(28), 2485–2494, 2016. (DOI)
  3. Kvasnica M, Oklešťková J, Bazgier V, Rárová L, Kořínková P, Mikulík J, Buděšínský M, Béres T, Berka K, Lu Q, Russinova E, Strnad M: Design, synthesis and biological activities of new brassinosteroid analogues with phenyl group in the side chain. Org. Biomol. Chem. , 14(37), 8691-8701, 2016. (DOI)
  4. Lamie PF, Ali WAM, Bazgier V, Rárová L: Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study. Eur. J. Med. Chem., 123, 803–813, 2016. (DOI)
  5. Nisler J, Kopečný D, Končitíková R, Zatloukal M, Bazgier V, Berka K, Zalabák D, Briozzo P, Strnad M, Spíchal L: Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase. Plant. Mol. Biol., 92(1), 235–248, 2016. (DOI)

2015

  1. Řezníčková E, Popa A, Gucký T, Zatloukal M, Havlíček L, Bazgier V, Berka K, Jorda R, Popa I, Nasereddin A, Jaffe CL, Kryštof V, Strnad M: 2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro. Bioorg. Med. Chem. Lett., 25(11), 2298-2301, 2015. (DOI)
  2. Řezníčková E, Weitensteiner S, Havlíček L, Jorda R, Gucký T, Berka K, Bazgier V, Zahler S, Kryštof V, Strnad M: Characterization of a Pyrazolo[4,3- d ]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro. Chem. Biol. Drug. Des., 86(6), 1528–1540, 2015. (DOI)

2014

  1. Kvasnica M, Oklešťková J, Bazgier V, Rárová L, Berka K, Strnad M: Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain. Steroids, 85, 58-64, 2014. (DOI)
  2. Mojzych M, Šubertová V, Bielawska A, Bielawski K, Bazgier V, Berka K, Gucký T, Fornal E, Kryštof V: Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines. Eur. J. Med. Chem., 78, 217-224, 2014. (DOI)

2013

  1. Gucký T, Jorda R, Zatloukal M, Bazgier V, Berka K, Řezníčková E, Béres T, Strnad M, Kryštof V: A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors. J. Med. Chem., 56(15), 6234-6247, 2013. (DOI)
  2. Havlíková M, Huličiak M, Bazgier V, Berka K, Kubala M: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase. Biochim. Biophys. Acta, Biomembr., 1828(2), 568-576, 2013. (DOI)
  3. Pozharitskaya O, Shikov A, Makarova M, Ivanova S, Kosman V, Makarov V, Bazgier V, Berka K, Otyepka M, Ulrichová J: Antiallergic Effects of Pigments Isolated from Green Sea Urchin (Strongylocentrotus droebachiensis) Shells. Planta Med., 79(18), 1698-1704, 2013. (DOI)