Mgr. Ing. Václav Bazgier
Tel: 58 563
4769, E-mail:
vaclav.bazgier@upol.cz, Room:
3.009
Research interests
- in silico drug design (molecular docking, chemoinformatics)
Education
- 2011 - VŠB – Technical University of Ostrava
- 2014 - University of Ostrava
Employment
- 2007 - 2009 - Department of Biochemistry, Faculty of Science, Palacky University
- 2009 - 2011 - Department of Immunology, Faculty of Medicine and Dentistry, Palacky University
- 2011 - 2013 - Department of Botany, Faculty of Science, Palacky University
Publication
2018
- Gucký T, Řezníčková E, Muchová RT, Jorda R, Klejová Z, Malíková V, Berka K, Bazgier V, Ajani H, Lepšík M, Divoký V, Kryštof V: Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl-N6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 mutations. J. Med. Chem., ASAP, 2018. (DOI)
- Šrejber M, Navrátilová V, Paloncýová M, Bazgier V, Berka K, Anzenbacher P, Otyepka M: Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners. J Inorg Biochem, ASAP, 2018. (DOI)
2017
- Carazo Fernández A, Hyrsova L, Dušek J, Chodounská H, Horvátová A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudová E, Pávek P: Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol. Lett., 265, 86–96, 2017. (DOI)
- Huličiak M, Bazgier V, Berka K, Kubala M: RH421 binds into the ATP-binding site on the Na+/K+-ATPase. Biochim. Biophys. Acta, Biomembranes, 1859(10), 2113–2122, 2017. (DOI)
- Kořínková P, Bazgier V, Oklešťková J, Rárová L, Strnad M, Kvasnica M: Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study. Steroids, 127, 46-55, 2017. (DOI)
2016
- Baltus CB, Jorda R, Marot C, Berka K, Bazgier V, Kryštof V, Prié G, Viaud-Massuard M: Synthesis, Biological Evaluation and Molecular Modeling of a Novel Series of 7-Azaindole Based Tri-Heterocyclic Compounds as Potent CDK2/Cyclin E Inhibitors. Eur. J. Med. Chem., 108(27), 701–719, 2016. (DOI)
- Bazgier V, Berka K, Otyepka M, Banáš P: Exponential repulsion improves structural predictability of molecular docking. J. Comput. Chem., 37(28), 2485–2494, 2016. (DOI)
- Kvasnica M, Oklešťková J, Bazgier V, Rárová L, Kořínková P, Mikulík J, Buděšínský M, Béres T, Berka K, Lu Q, Russinova E, Strnad M: Design, synthesis and biological activities of new brassinosteroid analogues with phenyl group in the side chain. Org. Biomol. Chem. , 14(37), 8691-8701, 2016. (DOI)
- Lamie PF, Ali WAM, Bazgier V, Rárová L: Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study. Eur. J. Med. Chem., 123, 803–813, 2016. (DOI)
- Nisler J, Kopečný D, Končitíková R, Zatloukal M, Bazgier V, Berka K, Zalabák D, Briozzo P, Strnad M, Spíchal L: Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase. Plant. Mol. Biol., 92(1), 235–248, 2016. (DOI)
2015
- Řezníčková E, Popa A, Gucký T, Zatloukal M, Havlíček L, Bazgier V, Berka K, Jorda R, Popa I, Nasereddin A, Jaffe CL, Kryštof V, Strnad M: 2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro. Bioorg. Med. Chem. Lett., 25(11), 2298-2301, 2015. (DOI)
- Řezníčková E, Weitensteiner S, Havlíček L, Jorda R, Gucký T, Berka K, Bazgier V, Zahler S, Kryštof V, Strnad M: Characterization of a Pyrazolo[4,3- d ]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro. Chem. Biol. Drug. Des., 86(6), 1528–1540, 2015. (DOI)
2014
- Kvasnica M, Oklešťková J, Bazgier V, Rárová L, Berka K, Strnad M: Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain. Steroids, 85, 58-64, 2014. (DOI)
- Mojzych M, Šubertová V, Bielawska A, Bielawski K, Bazgier V, Berka K, Gucký T, Fornal E, Kryštof V: Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines. Eur. J. Med. Chem., 78, 217-224, 2014. (DOI)
2013
- Gucký T, Jorda R, Zatloukal M, Bazgier V, Berka K, Řezníčková E, Béres T, Strnad M, Kryštof V: A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors. J. Med. Chem., 56(15), 6234-6247, 2013. (DOI)
- Havlíková M, Huličiak M, Bazgier V, Berka K, Kubala M: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase. Biochim. Biophys. Acta, Biomembr., 1828(2), 568-576, 2013. (DOI)
- Pozharitskaya O, Shikov A, Makarova M, Ivanova S, Kosman V, Makarov V, Bazgier V, Berka K, Otyepka M, Ulrichová J: Antiallergic Effects of Pigments Isolated from Green Sea Urchin (Strongylocentrotus droebachiensis) Shells. Planta Med., 79(18), 1698-1704, 2013. (DOI)